Features and Benefits:
- Proven Redness Reduction
- Improved Skin Health
- Superior Skin Soother
- Enhances Skin's Appearance
- Anti-Inflammatory Effects
- Reduces Likelihood of Post Inflammatory Pigmentation
INCI Name:
Water (and) Butylene Glycol (and) Camellia Sinensis (Tea) Extract (and)
Aspalathus Linearis (Rooibos) Extract (and) Boswellia Serrata Extract (and)
Honey Extract (and) Tetrapeptide-14 (and) Phenoxyethanol (and) Sodium Benzoate
Recommended Use Levels:
5%
Safety:
Non-irritating, Non-sensitizing
Availability:
Globally
Applications:
- Daily Wear
- Moisturizers
- Skin Toners
- Night Moisturizers
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Tetrapeptide-14 Delivery Matrix |
Granactive AR-1423 is a unique delivery matrix which combines a
redness diminishing peptide with the anti-oxidant properties of tea, the
calming properties of boswellia serrata and the soothing quality of honey.
Granactive AR-1423 contains Tetrapeptide-14, a
specific peptide sequence that can be used in cosmetic treatments to
alleviate the redness associated with rosacea or mild sun exposure. It
acts by down regulating interleukin-6 (IL-6) to prevent inflammation,
which in turn reduces MMP-1 damage with the net effect of a bright and
even skin appearance.
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Granactive AR-1423 Full Face Redness Study |
Granactive AR-1423 was evaluated in a leave-on cosmetic treatment
at a 5% level on several subjects having redness associated with rosacea.
This cosmetic treatment was effective at diminishing the redness by 50%
over the course of the 4 week study.
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Inflammation Due to UV-B Exposure |
UVB causes inflammation by increasing interleukin-6 in keratinocytes. The
IL-6 then induces fibroblasts to produce MMP-1 (matrix metalloproteinase-1),
an enzyme that breaks-down the extra-cellular matrix leading to photoaging.
The following dataset demonstrates the superior ability of tetrapeptide-14
to reduce IL-6 in keratinocytes and rapid reduce MMP-1 in fibroblasts to
simultaneously alleviate inflammation and photoaging.
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Puffy Eye Study |
A 6 week, 4 subjects study demonstrates tetrapeptide-14 dramatic reduction
of puffiness under the eye. The photo on the left displays tetrapeptide-14
ability to noticeably reduce puffiness in 2 weeks. A mean value of 42.86%
puffiness reduction was observed during the 6 week study.
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