Oligopeptide-10
A short bioactive peptide consisting of fifteen naturally occurring amino acids
that provides anti-microbial activity against p-acne bacterium
INCI Name:
Water (and) Butylene Glycol (and) Oryza Sativa (Rice) Bran Extract (and)
Boswellia Serrata Extract (and) Honey Extract (and) Oligopeptide-10
(and) Phenoxyethanol (and) Sodium Benzoate
Recommended use level:
5%
Patent Status:
Patent Pending Applications
Safety:
Non-cytotoxic, non-mutagenic, non-irritating, non-sensitizing
Availability:
Globally
Applications:
Anti-acne therapy products in serum, gel, cream and lotion forms
Formulation:
Water Dispersible
Maximum P.acne bacteria kill
Including antibiotic resistant bacterium
Low irritation and non-drying
Fast acting
Less reoccurrence
Aesthetically pleasant coverage
Exfoliating when mixed with Salicylic acid
Non-comedogenic
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Patent pending Oligopeptide-10 Composition for Acne Treatment
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Granactive ACNE is a botanical complex containing a patented
antimicrobial peptide for use in products associated with treating acne
symptoms. This product can be formulated with an approved OTC acne
ingredient, like salicylic acid or simply used in a toner to help maintain
healthy skin. Oligopeptide-10 is an anti-microbial peptide
derived from plant amino acids that is highly synergistic with salicylic
acid. This allows salicylic acid to be effectively formulated near the
0.5% level, the lowest permissible use level as defined in CFR Vol. 56,
No.159 §333.310c, the monograph for acne treatments. In comparison,
other products formulated near the 2% salicylic acid level are irritating.
Salicylic acid is comedolytic and opens up the infected pores to allow
oxygen in. This action also enables access of Oligopeptide-10
into the pores for a maximum bacteriostatic effect.
Oligopeptide-10 has broad-spectrum activity against many
types of organisms, including p. acne bacteria.
Rice Bran, Boswellia Serrata and Honey botanical extracts are included to
soothe and smooth the skin. Why not treat inflamed and infected skin with
something soothing?
We recommend formulating this product with InvisaSkin DS polymeric
technology to maximize delivery efficacy and hydration. InvisaSkin is a
non-comedogenic polymer that balances potential dryness from any other
ingredient, serves to deliver the peptide over 24 hours and simply feels
great!
It is estimated that 80-90% of all adolescents will have acne at some
point in the lives, and in some cases the acne will continue into
adulthood.
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Clinical Anti-Acne effect
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A four-week, "split-face" human panel test using multiple clinical
subjects demonstrated that Granactive ACNE with 0.5% Salicylic Acid and
0.5% InvisaSkin polymer (on % solids) significantly outperformed the
leading advertised benzoyl peroxide brand in reductions in comedones,
irritation, pustules and papules during the course of study
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Similar Improvements Relative to Leading Brand:
>20% Reduction in Total Papules
>40% Reduction in Pustules
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Targeted Effect and Delivery
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Bacterial digestion produces chemical products that may cause an
inflammatory reaction and pustule eruption. Other times, the gland opening
stays open but the oil is so thick that it doesn't flow out.
Human skin is comprised of two major classes of innate immunity peptide,
ß-defensins and cathelicidins (LL-37). Inflammation is often associated
with skin conditions that have bacterial involvement, which is in part due
to lipopoly-saccharide (LPS) released from the outer membrane of
gram-negative bacteria, and lipotechoic acid (LTA) released from
gram-positive bacteria. Innate immunity peptides such as defensins and
LL-37 are known for binding and neutralizing bacterial debris. This effect
down regulates pro-inflammatory cytokines.
Consistent with this LL-37 has also been shown to modulate the toll-like
receptor (TLR) mediated inflammatory response. Oligopeptide-10 is a
synthetic peptide designed to bind LTA.
Androgens are hormones that stimulate sebum production and are highest in
teens. When the oil gland exit gets choked shut by heavy sebum flow, the
bacteria multiply in their ideal environment: an oxygen poor closed comedone
(whitehead). Oxygen in the air then changes its color to black,
forming an open comedone (blackhead).
Salicylic Acid is comedolytic: it opens up the infected pores to drain,
allows oxygen in and enables free access of Oligopeptide-10 for maximum
bacteriostatic effect. We recommended using Salicylic Acid with
Granactive ACNE and InvisaSkin DS.
InvisaSkin hydrates up to 3x more water in skin and holds up to 20x it's
weight in water. The days of a drying anti-acne product are over. Just
formulate Salicylic acid, Granactive ACNE and InvisaSkin DS
to avoid moisture-sapping peroxides.
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Synergy Between Salicylate and Anti-microbial Peptide
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A study of sodium salicylate added to oligo-peptide-10 solutions found the
salicylate was instrumental in synergistically lowering the minimum
inhibitory concentration requirement for the peptide. In otherwords, 0.5%
salicylate is all that is required to meet the FDA guidelines and still
cause an 8X decrease in the amount of peptide required to kill over 50% of
the bacteria. This study exhibits the efficacy and value possible in using
salicylates with a peptide level of >2 ug/ml.
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New Approach to Treating Acne
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The unique combination of hydrating delivery vehicle and anti-microbial
peptide, when formulated with salicylic acid, offers a gentle approach to
treating the symptoms of acne.
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