Oligopeptide-10
A short bioactive peptide consisting of fifteen naturally occurring amino
acids that provides anti-microbial activity against p-acne bacterium
Features and Benefits:
Ready to dilute into an active containing water phase or improving an
existing o/w emulsion
Immediate perceptible difference in skin feel - smooth feeling initial
then transitions to powdery soft "Gransil Touch"
Contains Oligopeptide-10, an antimicrobial peptide originally
designed as a co-ingredient for healing and acne treatments
Cold processable in water based high performance systems
Formulation Advice:
Easily formulated in water systems at 60°C or below.
High Performance Polymer Matrix For Anti-acne
Granactive Oligopeptide-10 is a silicone-elastomer matrix featuring
a patented anti-microbial peptide from plant amino acids. Granactive
Oligopeptide-10 can be formulated with an approved OTC acne ingredient,
like salicylic acid, or simply used in a toner or other product for healthy
maintenance of the skin. While it has excellent activity against the
p-acne bacterium, it was found to be highly effective in combination with
salicylic acid. This allows salicylic acid to be synergistically formulated
near the 0.5% level, the lowest permissible use level for acne treatment.
In comparison, other products formulated near the 2% salicylic acid level
are much higher in irritation. Salicylic acid is comedolytic, opening up
the infected pores to allow oxygen in. This action enables
Oligopeptide-10 free access into the pores for a maximum
bacteriostatic effect. Promotes healthy skin tone while treating the
consumer to a sophisticated skin feel.
Procedure:
1. Add ingredients of part A, mix with side sweep agitation.
2. Add part B to part A with side sweep agitation, mix for 30 min.
Note:
If you are interested in a non-silicone based acne treatment, consider
Granactive ACNE, an aqueous solution
containing the proven anti-microbial peptide (INCI name oligopeptide-10)
for use in products associated with the treatment of acne. We recommend co-formulating
this product with salicylic acid and
InvisaSkin® DS
for optimal performance, delivery and treatment.
Additional Info:
Granactive Oligopeptide-10 contains about 0.03% antimicrobial peptide
sequence (active against p-acne), in a concentrated silicone elastomer gel
micro-dispersion for easy formulation.
This product is used in facial cosmetics as part of a greater anti-acne
treatment program.
Peptide Mechanism:
Human skin is comprised of two major classes of innate immunity peptide, §-defensins and
cathelicidins (LL-37). Inflammation is often associated with skin conditions that have
bacterial involvement, which is in part due to lipopoly-saccharide (LPS) released from the
outer membrane of gram-negative bacteria, and lipotechoic acid (LTA) released from
gram-positive bacteria. Innate immunity peptides such as defensins and LL-37 are known for
binding and neutralizing bacterial debris. This effect down regulates pro-inflammatory
cytokines.
Consistent with this LL-37 has also been shown to modulate the toll-like receptor (TLR)
mediated inflammatory response. Oligopeptide-10 is a synthetic peptide designed to bind LTA.
