Granactive
Oligopeptide-10

Sophisticated Anti-Acne and
Daily Wear Products

Specs & MSDS

Oligopeptide-10
A short bioactive peptide consisting of fifteen naturally occurring amino acids that provides anti-microbial activity against p-acne bacterium

Features and Benefits:

Ready to dilute into an active containing water phase or improving an existing o/w emulsion
Immediate perceptible difference in skin feel - smooth feeling initial then transitions to powdery soft "Gransil Touch"
Contains Oligopeptide-10, an antimicrobial peptide originally designed as a co-ingredient for healing and acne treatments
Cold processable in water based high performance systems

INCI Name:
Cyclopentasiloxane (and) Dimethicone (and) Water (and) Polysilicone-11 (and) Butylene Glycol (and) Decyl Glucoside (and) Oligopeptide-10

Recommended Use Levels:
10 - 30%

Safety:
Non-irritating, non-sensitizing, non-mutagenic

Availability:
Globally

Applications:

Anti-Acne
Daily Wear
Toners

Formulation Advice:
Easily formulated in water systems at 60°C or below.

High Performance Polymer Matrix For Anti-acne

Granactive Oligopeptide-10 is a silicone-elastomer matrix featuring a patented anti-microbial peptide from plant amino acids. Granactive Oligopeptide-10 can be formulated with an approved OTC acne ingredient, like salicylic acid, or simply used in a toner or other product for healthy maintenance of the skin. While it has excellent activity against the p-acne bacterium, it was found to be highly effective in combination with salicylic acid. This allows salicylic acid to be synergistically formulated near the 0.5% level, the lowest permissible use level for acne treatment. In comparison, other products formulated near the 2% salicylic acid level are much higher in irritation. Salicylic acid is comedolytic, opening up the infected pores to allow oxygen in. This action enables Oligopeptide-10 free access into the pores for a maximum bacteriostatic effect. Promotes healthy skin tone while treating the consumer to a sophisticated skin feel.

Oligopeptide-10 Acne Treatment Formula

Part	Ingredient	INCI Name	Wt (%)
A	Deionized Water	Water	59.05
	Natrosol 250M	Hydroxyethylcellulose	0.10
	Butylene Glycol	Butylene Glycol	15.00
	Tween-20	Polysorbate 20	0.15
	Plantaren 2000	Decyl Glucoside	0.20
	Salicylic Acid	Salicylic Acid	0.50
	Diocide	Caprylyl Glycol (and) Phenoxyethanol (and) Hexylene Glycol	0.50
	Granthix APP	Isohexadecane (and) Ammonium Polyacryloyldimethyl Taurate (and) Polysorbate 80	4.50
B	Granactive Oligopeptide-10	Cyclopentasiloxane (and) Dimethicone (and) Water (and) Polysilicone-11 (and) Butylene Glycol (and) Decyl Glucoside (and) Oligopeptide-10	20.00
Total:			100.00

Procedure:
1. Add ingredients of part A, mix with side sweep agitation.
2. Add part B to part A with side sweep agitation, mix for 30 min.

Note: If you are interested in a non-silicone based acne treatment, consider Granactive ACNE, an aqueous solution containing the proven anti-microbial peptide (INCI name oligopeptide-10) for use in products associated with the treatment of acne. We recommend co-formulating this product with salicylic acid and InvisaSkin^® DS for optimal performance, delivery and treatment.

Additional Info:

Granactive Oligopeptide-10 contains about 0.03% antimicrobial peptide sequence (active against p-acne), in a concentrated silicone elastomer gel micro-dispersion for easy formulation.

This product is used in facial cosmetics as part of a greater anti-acne treatment program.

Peptide Mechanism:
Human skin is comprised of two major classes of innate immunity peptide, §-defensins and cathelicidins (LL-37). Inflammation is often associated with skin conditions that have bacterial involvement, which is in part due to lipopoly-saccharide (LPS) released from the outer membrane of gram-negative bacteria, and lipotechoic acid (LTA) released from gram-positive bacteria. Innate immunity peptides such as defensins and LL-37 are known for binding and neutralizing bacterial debris. This effect down regulates pro-inflammatory cytokines.

Consistent with this LL-37 has also been shown to modulate the toll-like receptor (TLR) mediated inflammatory response. Oligopeptide-10 is a synthetic peptide designed to bind LTA.

Product Properties
Appearance	Translucent Gel
Viscosity (Brookfield DV-I+ Spindle T-E, 0.3 rpm, 1.0 min.)	800,000 - 1,200,000 cPs
Non-Volatile Matter, wt% (105°C, 3hrs, 1.5 g, gravity oven)	11.0 - 16.0
pH	5.5 - 7.5
Shelf Life	One Year in closed container

Formulas Demonstrating This Product

Anti-Blemish Primer - Demo Formula for Granactive Oligopeptide-10

GranactiveOligopeptide-10

Specs & MSDS

A

Plantaren 2000